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Thorne Research, Methyl-Guard, 180 Capsules

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Thorne Research, Methyl-Guard, 180 Capsules

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Thorne Research, Methyl-Guard, 180 Capsules

In Stock
  • Expiration Date: April 2019
  • Shipping Weight:
    0.24 kg
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  • Product Code: THR-78703
  • UPC Code: 693749787037
  • Package Quantity: 180 Count
  • Dimensions:
    13.2 x 7.4 x 7.4 cm , 0.2 kg
    Switch to Imperial units
Frequently Purchased Together
Product Overview


  • Dietary Supplement
  • Gluten Free
  • Heart/Vessels
  • Mood

Supports methylation for healthy heart, blood vessels, brain, and bones.

Methyl-Guard contains betaine, 5-MTHF, methyl-B12, and P5P to support healthy methylation for cardiovascular, cognitive, and bone health. Methylation helps maintain healthy homocysteine levels.

The body's methylation process is key to maintaining a healthy level of homocysteine, as well as to multiple other biochemical processes involving neurotransmitters, detoxification, cardiovascular health, eye health, muscle health, bone health, and redox balance. Maintaining a normal homocysteine level in the blood has joined having normal cholesterol and triglyceride levels as primary objectives for maintaining good cardiovascular health. Because Methyl-Guard promotes healthy methylation, it helps maintain heart, blood vessel, cognitive, nerve, bone, and female reproductive health. Methyl-Guard was the first nutritional supplement on the market to support homocysteine metabolism and healthy methylation using nutrients in their active, tissue-ready forms.

Methylation – the addition of a methyl group (CH3 – one carbon attached to three hydrogens) to another molecule – is an essential and vital biochemical process in the body involved in multiple biochemical pathways involving neurotransmitters, detoxification, cardiovascular health, eye health, muscle health, bone health, and redox balance. A number of specific nutrients are necessary for the process of methylation to occur normally.

Methylation is essential to help maintain a normal level of homocysteine. A deficiency in homocysteine-metabolizing cofactors is commonly seen in the elderly, resulting in an increase in homocysteine levels with advancing age. An elevated homocysteine level associated with aging, as well as low levels of folic acid and vitamins B6 and B12, often results in the decreased methylation of numerous substances, such as DNA and proteins, which in turn decreases the integrity of vascular structures and neurons. Providing nutritional cofactors for homocysteine metabolism also provides support for a healthy brain.

A number of biochemical imbalances that raise the level of homocysteine can be addressed by supplementing with appropriate nutrient cofactors. For example, folic acid (as L-5-methyltetrahydrofolate), vitamin B12 (as methylcobalamin), and betaine (trimethylglycine) help recycle homocysteine to the amino acid methionine, while the recycling of homocysteine into the beneficial amino acids cysteine and taurine is facilitated by pyridoxal 5'-phosphate (the active form of vitamin B6). Studies have shown these nutrients help maintain a normal level of homocysteine in the blood.

Because homocysteine levels can be higher in individuals in which the enzymatic reaction that converts folic acid to the active methyl donor L-5-methyltetrahydrofolate (5-MTHF) does not function properly, Methyl-Guard contains 400 mcg of active 5-MTHF per capsule.

Suggested Use

Take 3 capsules two times daily or as recommended by your health-care practitioner.

Other Ingredients

Hypromellose (derived from cellulose) capsule, silicon dioxide, calcium citrate, calcium laurate.


Tamper Evident: Use only if bottle is sealed.

If pregnant, consult your health-care practitioner before using this product.

Store tightly sealed in a cool, dry place.

Supplement Facts
Serving Size: Three Capsules
Servings Per Container: 60
  Three Capsules Contain: %DV
Vitamin B6 (as Pyridoxal 5'-Phosphate) 20.4 mg 1,200%
Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 2 mg DFE 500%
Vitamin B12 (as Methylcobalamin) 1.2 mg 50,000%
Betaine Anhydrous (Trimethylglycine) 1.8 g *
*Daily Value (DV) not established.
†This product uses Gnoisis S.p.A's L-5-Methyltetrahydrofolic Acid, Glucosamine salt (Quatrefolic)
iHerb Customer Reviews

Thorne Research, Methyl-Guard capsules

Posted by iHerb Customer on February 25 2018 | Verified Purchase

It's a Great Brand, a product aimed at helping people with a MTHFR 677TT Mutation that blocks absorption of folate. However it is advised that you introduce this supplement slowly and it works for some people but others not so much. It triggers dopamine and for me was a Calming Effect. It may give you vivid dreams, some people experience soreness in their joints. And some people tolerate it well and it's Wonderful, some people cannot tolerate it. It reduces histamines so it can be beneficial you just have to try it see for yourself.

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Posted by iHerb Customer on January 12 2018 | Verified Purchase


Thanks for your feedback!

product works

Posted by iHerb Customer on December 7 2017 | Verified Purchase

Helps with anxiety

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Posted by iHerb Customer on November 27 2017 | Verified Purchase

This product has quite simply changed my life around. A DNA test revealed that my body was not functioning properly, not absorbing B vitamins and generally methylation was poor. Methylation is the process of ridding the body of toxins. Combined with Glutatione Methyl-Guard has transformed me - I now actually sleep and I also know where to supplement with B vitamins.

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Supporting health with Thorn-Research

Posted by iHerb Customer on August 18 2017 | Verified Purchase

It helped!!! Now I have been able to move onto a different combination of vitamins and don't need it anymore, however when I did it helped.

Thanks for your feedback!