I take quite a few supplements (after carefully researching them) and I have to say this Enada NADH is one of the most amazing supplements. I was intrigued by NADH after reading about it on the Internet and I ordered a book about it by Dr. Birkmayer from amazon. I initially was interested in it for my mom, who has some dementia. I decided to try it myself first. I didn't expect to feel any differently until after using it for a month, as described on the directions, but I felt more energetic shortly after taking it. For instance, my eyes had been feeling very tired by midafternoon, and this fatigue disappeared the next day. I thought it was coincidence perhaps, but I haven't felt the eye fatigue since. Then, after about three weeks, I've been able to run longer and faster at the gym than I've ever been able to. I used to do just about 5 miles at the gym on good days, and just this week, I was able to run 5 1/2 miles for the first time ever. And I don't feel more tired either. Unfortunately, my mom can't use it because it made her feel nauseous and dizzy. I think it amplified the medications she is using because my dad said it was exactly the way he felt when he took her medication by mistake one day. So for now, she can't take it, and I'd advise anyone who is taking Abilify, Aricept or any similar medications to be careful about taking NADH as well.