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Mood support; Joint health; Liver function; Antioxidant support
Adults with busy lifestyles seeking simple daily mood and joint support or those wanting nutritional support for liver-related antioxidant processes.
Adults take 1 tablet 1 to 2 times daily on an empty stomach; if sensitive, start with 1 tablet once daily. Enteric-coated tablets are designed for release in the intestines.
Vegan; Gluten Free; No wheat, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame.
SAMe donates methyl groups in cellular reactions, which may support neurotransmitter synthesis, phospholipid formation, connective tissue sulphation, and glutathione production.
Caution: May cause digestive discomfort; take on an empty stomach as directed but reduce or pause if sensitive. Avoid use during pregnancy or breastfeeding and if you have bipolar disorder; SAMe can influence mood chemistry. Consult a professional before combining with antidepressants due to possible additive effects on neurotransmitters.
Label Warning: Do not use if pregnant or breastfeeding. Do not use if you have Parkinson’s disease, bipolar disorder, or manic depression. May cause gastrointestinal upset. Consult a healthcare professional before use if under 18, taking medication including antidepressants, SSRIs or MAO inhibitors, or have a medical condition. Stop use if adverse reactions occur.
Who should be cautious: People taking antidepressants, SSRIs or MAO inhibitors, and those with mood disorders or Parkinson’s disease should be cautious and seek personalised advice. Those with sensitive digestion may prefer to start with a lower dose or take with guidance. As SAMe may interact with serotonergic medications, consult a healthcare provider before combining with such medications.
Storage: Store in a cool, dry place. Keep out of the reach of children.
This product is guaranteed authentic and backed by our easy returns and refunds policy. Details
Glucosamine and chondroitin may support joint health and flexibility, complementing SAM-e's potential benefits for joint comfort.
AI generated. Not medical advice.
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Naturally Derived SAMe 200
Jarrow Formulas® SAMe 200 provides a full 200 mg SAMe (net yield) from 400 mg of SAMe tosylate disulfate. SAMe 200 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.
With More of the Biologically Active S,S than R,S Form
Found in all living cells, SAMe is a metabolite of methionine (an essential amino acid). SAMe is a chiral molecule consisting of two forms: (S,S) SAMe and (R,S) SAMe. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas® SAMe is made by microbiological fermentation and processed without chemical solvents to preserve 68-80% (S,S) SAMe.
SAMe supports:
Brain Metabolism and Mood
SAMe methylation reactions are involved in the synthesis of phosphatidylcholine, a substantial constituent of grey matter within the brain and cellular membranes. It has also been proposed to be involved in the formation or metabolism of neurotransmitters, which helps to support a balanced mood.
Joint Health
SAMe supports the production of healthy connective tissue through transsulfuration. In this transsulfuration process, critical components of connective tissue known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate, the building blocks of cartilage.
Liver Function
SAMe supports the synthesis of glutathione (GSH), which is critical for antioxidant defenses and liver functions including phase II detoxification.
Jarrow Formulas® SAMe 200 is foil blister-packed to maximise stability and provides 200 mg S-Adenosyl Methionine derived from 400 mg of SAMe Tosylate Disulphate.
EnteroGuard® is a proprietary cellulose-based, food-grade, pH-sensitive enteric coating that resists stomach acid and disintegrates in the less acidic pH of the upper intestines, where the SAMe is made available for absorption.
Adults take 1 tablet 1-2 times a day on an empty stomach or as directed by your qualified healthcare professional.
Microcrystalline cellulose, mannitol, coating (hypromellose acetate succinate), stearic acid [vegetable source], triethyl citrate, riboflavin), glyceryl behenate, magnesium stearate (vegetable source), silicon dioxide and sodium starch glycolate.
No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame.
Do not use if pregnant or breastfeeding. Individuals with Parkinson's disease, bipolar disorder, or manic depression should not use this product. May cause gastrointestinal upset in some individuals. Consult a healthcare professional before using this product if you are under the age of 18, are taking medication (antidepressants, selective serotonin reuptake inhibitors (SSRIs) and MAO inhibitors) or have a medical condition; if adverse reactions occur, discontinue use.
Keep out of the reach of children.
Store in a cool, dry place.
Do not use if the safety seal or blister is broken, damaged or missing.
While iHerb strives to ensure the accuracy of its product images and information, some manufacturing changes to packaging and/or ingredients may be pending update on our site. Although items may occasionally be despatched with alternative packaging, freshness is always guaranteed. We recommend that you read labels, warnings and directions of all products before use and do not rely solely on the information provided by iHerb. This website has been machine translated as a courtesy to customers. iHerb does not represent or warrant that the translations are complete or error-free and iHerb is not responsible for any translation errors or omissions.
| Supplement information | ||
| Serving Size: 1 Tablet | ||
| Amount Per Serving | %DV | |
| S-Adenosyl Methionine (from 400 mg of SAMe tosylate disulfate) | 200 mg | † |
| †Daily Value (DV) not established. | ||
