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Methylation support, energy metabolism, cardiovascular health, cognitive function, mood support
Adults with busy lifestyles seeking concentrated methylation-related B vitamins or those with limited intake of B-rich foods.
Take 1 to 3 capsules daily, preferably with food; splitting doses across the day may enhance tolerance for high-potency B vitamins.
Gluten Free. Manufactured in the UK using UK and imported ingredients.
Provides methyl groups that donate to homocysteine remethylation pathways, helping maintain balanced methylation activity.
Caution: High doses may cause gastrointestinal discomfort; start with a lower dose to assess tolerance.
Serves as a cofactor for methionine synthase, enabling remethylation of homocysteine and supporting methyl group transfer reactions.
Caution: Very high B12 may cause acneiform breakouts in some individuals; discontinue if this occurs.
Provides the active folate form that donates a methyl group to homocysteine via methionine synthase, supporting one‑carbon metabolism.
Caution: High-dose folate may mask signs of low vitamin B12; ensure adequate B12 status.
Active vitamin B6 supports transsulfuration and amino acid metabolism, influencing homocysteine handling and neurotransmitter synthesis.
Caution: Large amounts of vitamin B6 over time may cause tingling or numbness; do not exceed suggested use unless advised.
Active vitamin B2 supports enzymes in one‑carbon metabolism, including regeneration of 5‑MTHF through the MTHFR pathway.
Caution: High-dose riboflavin can cause bright yellow urine, which is harmless.
Trimethylglycine, methylcobalamin, and 5‑MTHF provide direct methyl donors for homocysteine remethylation. Riboflavin and pyridoxal‑5‑phosphate act as active coenzymes that facilitate one‑carbon metabolism and amino acid pathways, helping the methyl donors function efficiently across related routes.
Label Warning: If you are pregnant, consult a healthcare practitioner before use.
Who should be cautious: People with a history of vitamin B6 sensitivity or who experience tingling or numbness from high-dose B6 may wish to use caution and consider lower intake. Those with B12- or folate-related health concerns should seek personalised advice from a healthcare professional.
Storage: Store tightly sealed in a cool, dry place.
This product is guaranteed authentic and backed by our easy returns and refunds policy. Details
Magnesium and B vitamins may support energy production and reduce fatigue, promoting overall vitality and well-being.
AI generated. Not medical advice.
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Support cellular energy production, heart health, brain function, and mood with nutrients that optimise methylation
Methyl-Guard Plus provides superior methyl donors – trimethylglycine, 5-MTHF, and methylcobalamin – combined with bioactive vitamins B2 and B6 in a powerhouse formula for whole-body methylation support.
Take 1-3 capsules daily or as advised by a healthcare practitioner.
Hypromellose (derived from cellulose) capsule, calcium citrate, calcium laurate.
Manufactured in the UK using UK & Imported ingredients.
Tamper Evident: Use only if the bottle is sealed. Store tightly sealed in a cool, dry place.
If pregnant, consult your healthcare practitioner before using this product.
While iHerb strives to ensure the accuracy of its product images and information, some manufacturing changes to packaging and/or ingredients may be pending update on our site. Although items may occasionally be despatched with alternative packaging, freshness is always guaranteed. We recommend that you read labels, warnings and directions of all products before use and do not rely solely on the information provided by iHerb. This website has been machine translated as a courtesy to customers. iHerb does not represent or warrant that the translations are complete or error-free and iHerb is not responsible for any translation errors or omissions.
| Supplement information | ||
| Serving Size:Three Capsules | ||
| Servings Per Container:30 | ||
| Three Capsules Contain: | %DV | |
| Riboflavin (as Riboflavin 5'-phospate Sodium) | 90 mg | 6,923% |
| Vitamin B6 (as Pyridoxal-5-phosphate) | 45 mg | 2,647% |
| Folate (3 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) | 5 mg DFE | 1,250% |
| Vitamin B12 (as methylcobalamin) | 3 mg | 125,000% |
| Betaine Anhydrous (Trimethylglycine) | 1.8 g | * |
| *Reference Intake (DV) not established. †This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolic Acid, Glucosamine Salt (Quatrefolic). | ||
